SAMe (as S-adenosyl-L-methionine) is a naturally occurring metabolite found in the human body and in foods. It is an active methyl donor and is very important for healthy energy levels.

When vitamin B12 and folate are available, SAMe is naturally synthesized in humans from the amino acid methionine. SAMe is important for neurotransmitters, the 'sleep hormone' melatonin, phospholipids, and for cell health. It is also important for DNA methylation and healthy gene expression.