CCP Antibody

Information about ACP antibodies (a)

What is an ACPA test?

Cyclic citrullinated peptide antibodies are a type of antibody that can be present in the blood in those with an autoimmune disease known as Rheumatoid arthritis (RA).

They are directed against cyclic citrullinated peptides (CCP).  These antibodies can be elevated in someone with rheumatoid arthritis (RA). A CCP antibody test test detects and measures anti-CCP antibodies in the blood. It is used alongside a rheumatoid factor test to give a picture of RA risk and prognosis.

Why test ACPA?

Unless this is ordered as a retest or for a specific reason, we recommend ordering this as part of a health test.

Symptoms
You have symptoms of RA and the rheumatoid factor test was negative.

Family history
You have a family history of rheumatoid arthritis or similar autoimmune diseases.

Health check
Discover your risk factors for lifestyle diseases in time to do something about them.

What do the results mean?

RA is a clinical diagnosis made by considering symptoms in conjunction with tests. A doctor can diagnose you with rheumatoid arthritis even if both tests are negative if there are clear symptoms. Not everyone with rheumatoid arthritis has CCP antibodies in their bloodstream.

The ACPA/CCP antibody test can help diagnose RA in someone who has joint inflammation with symptoms that suggest but do not yet meet the criteria of RA.  It may be ordered along with a rheumatoid factor (RF) test, or if the RF result is negative.

Negative
A negative CCP test means that you do not have antibodies against CCP in your bloodstream.

Positive
A positive CCP test means that you have antibodies against CCP in your bloodstream. The ACPA/CCP antibody test can help diagnose RA in someone who has joint inflammation with symptoms that suggest but do not yet meet the criteria of RA and may be ordered along with RF or if the RF result is negative.

ACP antibodies are specific for rheumatoid arthritis. A positive test means a likely diagnosis of RA.  The presence of these antibodies may also predict the future development of RA and can be detected in healthy individuals many years before the onset of clinical or diagnosed RA.  However, these antibodies are not found in everyone with RA.

Using this test alongside the rheumatoid factor test gives the most complete picture of RA status and risk. Please note that rheumatoid arthritis is a clinical diagnosis, so it is very important to discuss these results and your symptoms with a rheumatologist.

Instructions
No advance preparation is needed for this test.

On the day of the test
Remember to take your I.D. with you when going to take a test.

Do not work out before going to do this test, as this may affect your results. Take this test before 10 am, as results can vary throughout the day. Arrive early and sit down quietly for 15 minutes before the test is taken.

Other information
This test is usually done alongside a rheumatoid factor test (link to below text) for a full analysis. This analysis is done daily. You can expect the results within 2-3 days.



 

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