Apolipoprotein A1 (2)

Information about Apolipoprotein (Apo) A1

What is Apolipoprotein (Apo) A1?

Apo A1 is a protein that is involved in lipid (fat) metabolism. It is the main protein component in high-density lipoprotein (HDL) cholesterol, higher levels of which seem to have health benefits in healthy individuals.

Why test Apolipoprotein (Apo) A1?
Apo A1 is a marker of heart health and risk of heart and artery disease and is included in many of our test packages.

Health Check
Discover your risk factors for cardiovascular diseases in time to do something about them. Health History
Your lifestyle, personal or family history suggests an increased risk of cardiovascular disease. Chronic inflammation, elevated triglycerides, and high blood sugar are common risk factors. Monitoring
Monitor changes to your blood values as you make lifestyle changes, supplement or undergo treatments. 

What do the test results mean?

What causes low Apo A1 levels?
Low levels of Apo A1 are associated with low levels of HDL, the so-called ‘good’ cholesterol, and impaired cholesterol clearance from the body. Lower Apo A1, combined with higher Apo B is associated with increased rates of cardiovascular disease.  Having a higher level of Apo A1 is considered protective against cardiovascular disease. The ApoA1 to Apo B ratio is considered one of the most accurate ways to determine the risk of cardiovascular disease and can predict the risk of having a heart attack no matter the cholesterol and triglyceride levels.

Low levels of Apo A1 can be caused by some health conditions such as kidney disease, diabetes, obesity/overweight, certain medications, or lifestyle choices such as smoking and poor diet. Genetic factors can also lead to deficiencies in Apo A1 (and thus low levels of HDL). People with these disorders tend to have abnormal lipid levels, including high levels of low-density lipoprotein (LDL – the "bad" cholesterol). Frequently, they have accelerated rates of atherosclerosis. These genetic disorders are the primary causes of low Apo A1.

Changes in levels of Apo A-I may also be associated with other factors. The following may decrease Apo A1: chronic kidney disease, certain drugs (androgens, beta-blockers, diuretics, and progestins (synthetic progesterone)), smoking, untreated diabetes, and obesity.  What causes high Apo A1 levels?
High values may reduce the risk of heart and artery disease.  The following may increase Apo A1: Genetic factors, physical activity, and hormones, moderate alcohol consumption, medications like carbamazepine, estrogens, ethanol, lovastatin, niacin, oral contraceptives, phenobarbital, pravastatin, and simvastatin, physical activity, pregnancy, weight loss, statins. More Information
Values that are slightly outside the reference range can be normal. Reference ranges are not perfect and approximately 5% of healthy individuals may have results outside the reference range. Instructions The day before the test Avoid fatty foods and alcohol today On the day of the test Remember to take your ID. with you when going to take a test. Arrive in good time and sit down quietly for 15 minutes before the test is taken.
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