Transferrin Saturation %

What is transferrin saturation %?

Transferrin Saturation % is an estimate, based on other iron markers, of how many of transferrin iron-binding sites are being used.

In normal iron status, transferrin is usually one-third saturated with iron, so roughly two-thirds of its capacity is held in reserve. The iron concentration may be divided by the transferrin concentration, not the TIBC. This similar estimate is usually called the transferrin index.)

Why test transferrin saturation %?

Regular iron testing can be important for various reasons. A diet lacking meat, seafood, iron, vitamin B12, and folate can increase the risk of Iron Deficiency Anemia (IDA). Identifying risk factors for lifestyle diseases, such as anaemia and hemochromatosis, allows timely intervention. Monitoring blood values helps track changes as you adjust your diet, take supplements, or undergo treatments. Individuals with a personal or family history of anaemia or excess iron should test regularly. Heavy periods, pregnancy, and athletic activities also elevate the risk of iron imbalance. Symptoms of low iron include fatigue, dizziness, and pale skin, while high iron can cause fatigue, joint pain, and liver disease.

What causes low transferrin saturation?

Low transferrin saturation is most often caused by iron deficiency anaemia (IDA).

What causes high transferrin saturation?

High transferrin saturation is most often caused by iron overload (hemochromatosis).  It can also be caused by iron poisoning.

More information
Recent blood transfusions, iron injections and transfusions can all affect the results of iron tests.

Preparations for this test

If you take iron supplements, avoid them for 24 hours before doing this test

On the day of the test
Always take your ID with you when going to take a test.


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